Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Moderately Good
Based on 58 Reviews
7.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Calcium (from Aquamin®)
80 mg
6%
UC-II® Standardized Chicken Cartilage(Providing 10 mg Total Collagen, including Undenatured Type II Collagen)
40 mg
†
Aquamin® (Seaweed Derived Minerals) (Lithothamnium spp.) (Whole Plant)
250 mg
†
Top Medical Research Studies
We investigated whether collagen supplements could ease pain and improve quality of life for patients with knee meniscus issues. This randomized, double-blind, placebo-controlled study involved 32 participants, half receiving collagen and half a placebo.
After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.
After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.
Read More
8
We investigated the effects of specific collagen peptides on knee pain in athletes experiencing functional issues. Over 12 weeks, 139 participants took either 5 g of these peptides or a placebo daily.
Participants reported a noticeable reduction in activity-related pain, which was confirmed by physicians.
While resting pain also improved, it wasn't statistically significant. Additionally, those taking collagen needed fewer additional treatments. Overall, collagen peptides appear to be an effective option for managing knee pain during physical activity.
Participants reported a noticeable reduction in activity-related pain, which was confirmed by physicians.
While resting pain also improved, it wasn't statistically significant. Additionally, those taking collagen needed fewer additional treatments. Overall, collagen peptides appear to be an effective option for managing knee pain during physical activity.
Read More
9
This study set out to determine if oral collagen supplements could help treat knee pain linked to osteoarthritis caused by ACL injury in rats.
We found that different types of collagen, especially the protease-soluble chicken type II collagen, not only reduced pain sensitivity but also improved cartilage health.
Rats given collagen showed significant improvements compared to those who didn't receive it, leading to better joint function and less inflammation.
Overall, collagen treatment appears beneficial for managing knee pain related to osteoarthritis.
We found that different types of collagen, especially the protease-soluble chicken type II collagen, not only reduced pain sensitivity but also improved cartilage health.
Rats given collagen showed significant improvements compared to those who didn't receive it, leading to better joint function and less inflammation.
Overall, collagen treatment appears beneficial for managing knee pain related to osteoarthritis.
Read More
Most Useful Reviews
9
Surprisingly effective
25 people found this helpful
After a month of taking this supplement, the crunch and discomfort in my knees and injured elbow vanished. I noticed improvement in my lower back as well, which has a classic L3-L4 hernia. I was pleasantly surprised by this effect and will continue using it.
Read More
9
Effective prevention drug
13 people found this helpful
A good product, particularly for prevention. My knee has stopped hurting.
Read More
8
Knee pain relief
6 people found this helpful
I waited before writing this. After a month of taking it, I've noticed that the ache in my knees has not returned. A few years ago, I tore tendons in both knees and tried glucosamine after physiotherapy, but it didn't help much. However, Type II Collagen seems to make my joints more supple and ready for action.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
- All Researches
We investigated the effects of a dietary supplement containing hydrolyzed collagen, chondroitin sulfate, glucosamine, turmeric extract, and devil's claw on knee pain and function in osteoarthritis patients.
In a study with 186 participants over six months, they reported a significant decrease in pain and improved joint function. Measures showed noticeable pain relief at both three and six months, as well as enhancements in overall functioning.
Comfortingly, there were no severe side effects noted during the observation period.
In a study with 186 participants over six months, they reported a significant decrease in pain and improved joint function. Measures showed noticeable pain relief at both three and six months, as well as enhancements in overall functioning.
Comfortingly, there were no severe side effects noted during the observation period.
Read More
9
This study set out to determine if oral collagen supplements could help treat knee pain linked to osteoarthritis caused by ACL injury in rats.
We found that different types of collagen, especially the protease-soluble chicken type II collagen, not only reduced pain sensitivity but also improved cartilage health.
Rats given collagen showed significant improvements compared to those who didn't receive it, leading to better joint function and less inflammation.
Overall, collagen treatment appears beneficial for managing knee pain related to osteoarthritis.
We found that different types of collagen, especially the protease-soluble chicken type II collagen, not only reduced pain sensitivity but also improved cartilage health.
Rats given collagen showed significant improvements compared to those who didn't receive it, leading to better joint function and less inflammation.
Overall, collagen treatment appears beneficial for managing knee pain related to osteoarthritis.
Read More
We investigated whether collagen supplements could ease pain and improve quality of life for patients with knee meniscus issues. This randomized, double-blind, placebo-controlled study involved 32 participants, half receiving collagen and half a placebo.
After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.
After eight weeks, we noted that those taking collagen reported reduced pain and enhanced quality of life, along with improvements in some physical tests. While the results are promising, more extensive studies are needed to explore long-term benefits and outcomes for different patient groups.
Read More
8
This clinical study aimed to evaluate how collagen supplements might ease knee pain related to osteoarthritis.
We involved 31 participants in a controlled setting, comparing those taking collagen with a placebo group over eight weeks.
The findings indicated that collagen supplementation led to improvements in pain levels and quality of life. Some aspects of physical function also showed positive changes, highlighting collagen's potential benefits for those suffering from knee issues.
We involved 31 participants in a controlled setting, comparing those taking collagen with a placebo group over eight weeks.
The findings indicated that collagen supplementation led to improvements in pain levels and quality of life. Some aspects of physical function also showed positive changes, highlighting collagen's potential benefits for those suffering from knee issues.
Read More
8
We conducted a study to see how effective a herbal supplement, NXT15906F6 (also known as TamaFlex), is in reducing knee pain and joint inflammation, specifically in a rat model of osteoarthritis. The rats were divided into groups and received either this supplement or a standard medication called Celecoxib over 28 days.
Post-treatment results revealed that NXT15906F6 significantly decreased joint pain and inflammation, while also improving the overall joint condition. The study showed promising signs by reducing harmful proteins that can cause joint damage. This suggests that NXT15906F6 could be a beneficial option for managing knee pain more effectively.
Post-treatment results revealed that NXT15906F6 significantly decreased joint pain and inflammation, while also improving the overall joint condition. The study showed promising signs by reducing harmful proteins that can cause joint damage. This suggests that NXT15906F6 could be a beneficial option for managing knee pain more effectively.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 58 Reviews
7.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Surprisingly effective
25 people found this helpful
After a month of taking this supplement, the crunch and discomfort in my knees and injured elbow vanished. I noticed improvement in my lower back as well, which has a classic L3-L4 hernia. I was pleasantly surprised by this effect and will continue using it.
Read More
9
Effective prevention drug
13 people found this helpful
A good product, particularly for prevention. My knee has stopped hurting.
Read More
8
Knee pain relief
6 people found this helpful
I waited before writing this. After a month of taking it, I've noticed that the ache in my knees has not returned. A few years ago, I tore tendons in both knees and tried glucosamine after physiotherapy, but it didn't help much. However, Type II Collagen seems to make my joints more supple and ready for action.
Read More
9
Improved discomfort
5 people found this helpful
I’ve repurchased this product numerous times. My mother’s knee discomfort improved significantly after taking it. The small capsules are convenient to swallow, making it a very good product overall.
Read More
9
Quick results
5 people found this helpful
After taking glucosamine, the discomfort in my knees persisted, but after a little over a week, it vanished. I'm very pleased with the results.
Read More
Frequently Asked Questions
9
Surprisingly effective
25 people found this helpful
After a month of taking this supplement, the crunch and discomfort in my knees and injured elbow vanished. I noticed improvement in my lower back as well, which has a classic L3-L4 hernia. I was pleasantly surprised by this effect and will continue using it.
8
Knee pain relief
6 people found this helpful
I waited before writing this. After a month of taking it, I've noticed that the ache in my knees has not returned. A few years ago, I tore tendons in both knees and tried glucosamine after physiotherapy, but it didn't help much. However, Type II Collagen seems to make my joints more supple and ready for action.
9
Significant improvement
4 people found this helpful
Prominent Benefit: It positively affects my knee joints. I have improved significantly with no cracking in my knees. I take 2 capsules in the morning on an empty stomach. Within one week, I felt considerable improvement. There are no allergies or side effects. The economical packaging is an added bonus, and the expiry date is excellent, allowing me to use the product without concern. It works effectively and is safe.
9
Quick results
5 people found this helpful
After taking glucosamine, the discomfort in my knees persisted, but after a little over a week, it vanished. I'm very pleased with the results.
7.5
Effective for elders
4 people found this helpful
I bought UCII for my elderly family member who has suffered from knee joint problems for years. After a month of use, she mentioned feeling great improvement. I’m pleased with its effectiveness, so I will continue purchasing it.
9
Relieves knee pain
2 people found this helpful
I believe it has alleviated my left knee issues related to meniscus and cartilage damage. I felt quite soothed after several weeks of use alongside type 1 (hydrolysed) collagen from another brand.
9
Knee discomfort gone
3 people found this helpful
Non-denatured type 2 collagen is effective if taken when hungry before bed. The discomfort in my knee has disappeared.
8
This clinical study aimed to evaluate how collagen supplements might ease knee pain related to osteoarthritis.
We involved 31 participants in a controlled setting, comparing those taking collagen with a placebo group over eight weeks.
The findings indicated that collagen supplementation led to improvements in pain levels and quality of life. Some aspects of physical function also showed positive changes, highlighting collagen's potential benefits for those suffering from knee issues.
We involved 31 participants in a controlled setting, comparing those taking collagen with a placebo group over eight weeks.
The findings indicated that collagen supplementation led to improvements in pain levels and quality of life. Some aspects of physical function also showed positive changes, highlighting collagen's potential benefits for those suffering from knee issues.
We investigated the effects of a dietary supplement containing hydrolyzed collagen, chondroitin sulfate, glucosamine, turmeric extract, and devil's claw on knee pain and function in osteoarthritis patients.
In a study with 186 participants over six months, they reported a significant decrease in pain and improved joint function. Measures showed noticeable pain relief at both three and six months, as well as enhancements in overall functioning.
Comfortingly, there were no severe side effects noted during the observation period.
In a study with 186 participants over six months, they reported a significant decrease in pain and improved joint function. Measures showed noticeable pain relief at both three and six months, as well as enhancements in overall functioning.
Comfortingly, there were no severe side effects noted during the observation period.
7
We examined the effectiveness of dietary supplements, including collagen, for treating knee pain in osteoarthritis patients. The review analyzed multiple studies, highlighting that while some supplements showed promising short-term benefits for pain relief, the overall quality of evidence was very low.
Notably, widely used options like glucosamine and chondroitin showed minimal impact and lacked significant long-term benefits. In the end, collagen may provide temporary relief, but it's not a guaranteed solution for everyone.
Notably, widely used options like glucosamine and chondroitin showed minimal impact and lacked significant long-term benefits. In the end, collagen may provide temporary relief, but it's not a guaranteed solution for everyone.
7
We investigated how daily collagen peptide (CP) supplementation impacts knee pain and overall function in healthy, active middle-aged adults. In a well-structured double-blind trial, participants were given either a placebo or 10 to 20 grams of CP daily over 6 to 9 months.
The results revealed that 10 grams of CP significantly improved daily activities and pain levels, particularly in those who exercised frequently. Additionally, mental and physical health scores saw positive changes with consistent CP intake. This suggests that collagen supplements can be beneficial for managing knee pain and enhancing quality of life in active adults.
The results revealed that 10 grams of CP significantly improved daily activities and pain levels, particularly in those who exercised frequently. Additionally, mental and physical health scores saw positive changes with consistent CP intake. This suggests that collagen supplements can be beneficial for managing knee pain and enhancing quality of life in active adults.
8
We investigated the effects of specific collagen peptides on knee pain in athletes experiencing functional issues. Over 12 weeks, 139 participants took either 5 g of these peptides or a placebo daily.
Participants reported a noticeable reduction in activity-related pain, which was confirmed by physicians.
While resting pain also improved, it wasn't statistically significant. Additionally, those taking collagen needed fewer additional treatments. Overall, collagen peptides appear to be an effective option for managing knee pain during physical activity.
Participants reported a noticeable reduction in activity-related pain, which was confirmed by physicians.
While resting pain also improved, it wasn't statistically significant. Additionally, those taking collagen needed fewer additional treatments. Overall, collagen peptides appear to be an effective option for managing knee pain during physical activity.
References
- Genç AS, Yılmaz AK, Anıl B, Korkmaz Salkılıç E, Akdemir E, et al. The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy: a randomized, double-blind, placebo-controlled study. BMC Musculoskelet Disord. 2025;26:17. 10.1186/s12891-024-08244-w
- Genç AS, Yılmaz AK, Anıl B, Korkmaz Salkılıç E, Akdemir E, et al. Effect of supplementation with type 1 and type 3 collagen peptide and type 2 hydrolyzed collagen on osteoarthritis-related pain, quality of life, and physical function: A double-blind, randomized, placebo-controlled study. Jt Dis Relat Surg. 2025;36:85. 10.52312/jdrs.2025.1965
- Puigdellívol Grifell J, Comellas Berenguer C, Steinbacher G, Kranjcec T, Álvarez Díaz P, et al. Open, Observational, Single-Arm, Multicenter Study Assessing the Effectiveness of a Dietary Supplement Containing Hydrolyzed Collagen, Chondroitin Sulfate, and Glucosamine for Osteoarthritis Pain Reduction. J Diet Suppl. 2024;21:374. 10.1080/19390211.2023.2284982
- Thomas DT, Prabhakar AJ, Eapen C, Patel VD, Palaniswamy V, et al. Comparison of Single and Combined Treatment with Exercise Therapy and Collagen Supplementation on Early Knee Arthritis among Athletes-A Quasi-Randomized Trial. Int J Environ Res Public Health. 2023;20. 10.3390/ijerph20237088
- van Dam L, Terink R, Mensink M, de Vos RJ, Zwerver J. The JUMPFOOD study: additional effect of hydrolyzed collagen and vitamin C to exercise treatment for patellar tendinopathy (jumper's knee) in athletes-study protocol for a double-blind randomized controlled trial. Trials. 2023;24:768. 10.1186/s13063-023-07783-2
- Yves H, Herman J, Uebelhoer M, Wauquier F, Boutin-Wittrant L, et al. Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation. BMC Musculoskelet Disord. 2023;24:748. 10.1186/s12891-023-06800-4
- Chen NF, Lin YY, Yao ZK, Tseng CC, Liu YW, et al. Oral Administration of Protease-Soluble Chicken Type II Collagen Ameliorates Anterior Cruciate Ligament Transection-Induced Osteoarthritis in Rats. Nutrients. 2023;15. 10.3390/nu15163589
- Kviatkovsky SA, Hickner RC, Cabre HE, Small SD, Ormsbee MJ. Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults. J Int Soc Sports Nutr. 2023;20:2243252. 10.1080/15502783.2023.2243252
- Kwon SB, Chinta G, Kundimi S, Kim S, Cho YD, et al. A Blend of and Extracts Alleviates Monosodium Iodoacetate (MIA)-Induced Osteoarthritic Pain and Joint Inflammation in Rats. J Am Nutr Assoc. 2024;43:48. 10.1080/27697061.2023.2209880
- Chen CC, Chang SS, Chang CH, Hu CC, Nakao Y, et al. Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joint, bone, and muscle functions. Nutr J. 2023;22:17. 10.1186/s12937-023-00837-w
- Shavlovskaya OA. [Complex effects of physical exertion with dietary supplements Cartilox in pain syndrome effectiveness and safety evaluation]. Vopr Kurortol Fizioter Lech Fiz Kult. 2022;99:20. 10.17116/kurort20229904120
- Mohammed A, He S. A Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy of a Hydrolyzed Chicken Collagen Type II Supplement in Alleviating Joint Discomfort. Nutrients. 2021;13. 10.3390/nu13072454
- Lee HS, Oh KJ, Moon YW, In Y, Lee HJ, et al. Intra-articular Injection of Type I Atelocollagen to Alleviate Knee Pain: A Double-Blind, Randomized Controlled Trial. Cartilage. 2021;13:342S. 10.1177/1947603519865304
- García-Coronado JM, Martínez-Olvera L, Elizondo-Omaña RE, Acosta-Olivo CA, Vilchez-Cavazos F, et al. Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials. Int Orthop. 2019;43:531. 10.1007/s00264-018-4211-5
- Liu X, Machado GC, Eyles JP, Ravi V, Hunter DJ. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. Br J Sports Med. 2018;52:167. 10.1136/bjsports-2016-097333
- Zdzieblik D, Oesser S, Gollhofer A, König D. Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. Appl Physiol Nutr Metab. 2017;42:588. 10.1139/apnm-2016-0390
